The Orange Pill Podcast

Episode 19: KGK Science and Nimble Science: Revolutionizing GI Health Research

In this episode of the Orange Pill Podcast, we talk about the exciting new partnership between KGK Science and Nimble Science. Learn how this collaboration is set to redefine gastrointestinal (GI) health research through the integration of SIMBA™, a novel ingestible capsule that collects high-quality gut samples—without invasive procedures.

Episode 18: RFK Jr.'s FDA Food Safety Agenda

In this episode, we dive into U.S. presidential candidate Robert F. Kennedy Jr.’s provocative vision for the future of food regulation. RFK Jr. is calling for nothing short of a revolution—taking aim at food chemicals, plastics, and the FDA’s current approach to food safety.
We unpack his stance on rethinking Generally Recognized as Safe (GRAS) determinations, his plan to reform the FDA’s oversight of food additives and endocrine disruptors, and what this could mean for food manufacturers, consumers, and the natural health industry.

Episode 17: Yeast Postbiotic Effect On Cold And Flu In Children

In this episode, we unpack a compelling clinical study conducted by KGK Science for Cargill on the impact of EpiCor® postbiotic supplementation in children. Learn how a daily gummy dose of this yeast-derived ingredient significantly reduced cold and flu symptoms, limited the need for medication, and offered a safe, science-backed immune support option for kids aged 4 to 12. Plus, we explore why this study is a milestone in both postbiotic and gummy supplement research.

Episode 16: New Vitamin D Meta Analysis Study Shows no Benefit on Upper Respiratory Illness

In this episode, we dive into a recent Lancet meta-analysis that questions vitamin D’s effectiveness in preventing acute respiratory infections. What does the data actually say, and how should consumers respond?
We also explore promising new findings from Pediatric Research on EpiCor, a postbiotic that may reduce cold and flu symptom severity in children. KGK Science contributed to this important study—hear what the results mean for immune health innovation and the supplement industry at large.

Episode 15: Upcoming Trends in 2025 for the Dietary Supplement Industry

In this forward-looking episode, we explore the major shifts on the horizon for the dietary supplement and nutraceuticals sector in 2025. Expect a transformation driven by sustainability, science, and personalization. We cover:
The rise of plant-based and functional ingredients
Personalized nutrition through genomics and AI
Regulatory updates on GRAS and novel ingredients
The role of eco-conscious practices and clean-label demands
Digital health tech and real-time supplement customization
Insights into cutting-edge clinical research, like KGK’s study on immune health in children
If you're in the industry—or just passionate about where wellness is headed—this is an episode you don't want to miss.

Episode 14: Disturbing New Trend in CRO Research- Use of Predicted Margins

In this episode, we explore a growing issue in nutraceutical clinical research: the misuse of predicted margins to gloss over incomplete data in virtual trials. When predictive models are used in place of raw results—without validation or transparency—scientific rigor is compromised. We break down what predicted margins are, when they should (and shouldn’t) be used, and how this impacts regulatory credibility.

Episode 13: FDA's Final Rule for 'Healthy'

In this episode, we explore the FDA’s newly finalized definition of “healthy” for food labeling — a major regulatory update released in December 2024. The goal? To bring food labels in line with today’s nutrition science and help consumers make better choices.
We unpack what’s changed, why it matters, and how these new rules will impact how companies across both the supplement and conventional food spaces position their products moving forward.

Episode 12: Benefits of Fava Beans on Resistance Training

In this episode, we discuss a new clinical trial conducted by KGK Science and published in the British Medical Journal of Nutrition, Prevention and Health. This randomised, double-blind, placebo-controlled study evaluated how supplementation with a fava bean protein supplement impacts human strength and endurance when combined with resistance training.
 

Episode 11: Virtual Trials for Dietary Supplements and Conventional Foods

In this episode of the Orange Pill Podcast, we explore the growing trend of virtual clinical trials in the dietary supplement and conventional food industries. Learn how these innovative trial designs are making research more accessible, efficient, and data-driven. 

Episode 10: Update of Kennedy Reform of FDA Operations

In this episode of the Orange Pill Podcast, we explore the evolving landscape of federal health agencies under the leadership of Secretary Robert Kennedy Jr. We’ll take a closer look at the potential reforms he aims to implement at the FDA and how these changes could impact the industry.
From Kennedy's well-documented policy positions to recent initiatives by the Trump administration and the latest developments at HHS, we’re unpacking it all.