The Orange Pill Podcast

Episode 28: Natural Relief- The Science Behind Relieve-R and Its Role in Pain Management

In this episode, we unpack a fascinating clinical trial conducted by KGK Science for LifeSeasons Inc., evaluating the natural health product Relieve-R (formerly Pain Bloc-R) as an alternative for occasional pain relief and inflammation.
Published in the journal Nutrients, this randomized, double-blind, placebo-controlled crossover study compared Relieve-R to acetaminophen and placebo across three 7-day supplementation periods.
The results? Relieve-R significantly reduced pain severity and musculoskeletal discomfort, showing comparable—and in some areas, superior—effectiveness to acetaminophen, all with a favorable safety profile.
We explore what this means for the future of natural pain relief, how the study was designed, and why clinical validation matters in the nutraceutical space.
 

Episode 27: A Novel trial design by KGK Science on Unigen’s UP446 Ingredient to Demonstrate a Positive Immune Defense Response

In this episode, we explore an innovative clinical trial by KGK Science evaluating Unigen’s UP446, a natural health ingredient composed of Acacia catechu and Scutellaria baicalensis. Designed as a randomized, triple-blind, placebo-controlled study, this trial used a human vaccine model to assess immune response following influenza vaccination. 
We discuss the implications of this design, the significance of the findings, and how UP446 may play a vital role in supporting respiratory health—particularly during flu season. Join us as we speak about what this research means for the future of natural health products. 

Episode 26- FDA Continues to Allow Companies to Use NDIs Submitted by Competitors - the Practice of Piggybacking

In this episode on the Orange Pill Podcast, we tackle a long-standing regulatory loophole: piggybacking on NDI submissions. While companies like Natural Alternatives International (NAI) invest in proper safety and regulatory filings, like their recent successful NDI notification for CarnoSyn® beta-alanine, authored by the regulatory team at KGK Science, others sidestep the process entirely.
The FDA’s lack of enforcement has allowed un-notified, and in many cases counterfeit or imported ingredients, to remain on the market, undermining consumer safety and disincentivizing compliance.
We break down:
What piggybacking is and why it’s problematic
The implications of the CarnoSyn® beta-alanine NDI success
NAI’s push for stronger FDA enforcement
How this issue reflects broader weaknesses in DSHEA enforcement
A must-listen for industry professionals, regulatory stakeholders, and anyone invested in the future of dietary supplement safety.

Episode 25: MAHA Commission Report – Big Beautiful (FDA) Blueprint

The MAHA Commission Report is expected to be released today—and it’s already making waves. In this special pre-release episode, we explore what to expect from the report, and how it could reshape conversations around policy, governance, and the future.
As the noise ramps up, we give you the context and clarity you’ll need to navigate the headlines. From structural insights to potential implications, we break it all down before the official release lands.
Get ahead of the narrative. Tune in now.

Episode 24: Nestle Launches Salmon Oil Supplement with Hofseth's OmeGo

In this episode, we explore Nestlé’s U.S. debut of a salmon oil supplement under the Garden of Life brand, featuring OmeGo — a unique whole fish extract by Hofseth Biocare. We break down what makes this omega-3 product stand out in a crowded market, the role of sustainability and full-spectrum benefits, and how KGK Science supported Hofseth in obtaining the crucial NDI status that paved the way for this launch. 
Tune in for an inside look at the intersection of innovation, regulatory success, and industry impact. 

Episode 23: Sustainability: The Future of the Dietary Supplement Industry

As consumer demand grows for clean, conscious products, the supplement industry is being called to evolve.
In this episode, we explore the many ways companies can engage in sustainable sourcing and production—from eco-friendly packaging and ethical ingredient procurement to promoting responsible consumer practices.
Learn how reducing plastic waste, sourcing local or organic ingredients, and embracing circularity can help your brand lead the change—and why it’s no longer optional.

Episode 22: Pollen Extracts for Female Urinary incontinence

In this episode, we explore how flower pollen extracts are being studied as a potential solution for urinary incontinence in women. We break down the latest clinical evidence from a newly published trial in Current Urology, conducted by KGK Science and sponsored by Graminex®.
We’ll discuss:
The impact of urinary incontinence on daily life
How flower pollen extracts may support urinary health
Key findings from the clinical trial
What this means for the future of women’s health and nutraceuticals
Don't miss this deep dive into one of the most under-discussed yet important areas of women's health.

Episode 21: The Sleep Secret Hidden in Corn Leaves

We are back with a deep dive into the world of sleep — and why melatonin may not be the long-term solution we’ve all been promised.
In this episode we cover:
Why melatonin is widely used in hospitals, yet many still struggle to sleep
What makes sleep so critical to overall health
The growing global demand for new, effective sleep supplements
A look at Maizinol®, a natural sleep aid derived from corn leaves, clinically shown to improve REM sleep, reduce sleep latency, and extend overall sleep time — all from a single dose. The science is in, and the results are impressive.

Episode 20: History of the US Food Supply : Before and After FDA

In this episode, we uncover the shocking state of America’s food supply before the FDA — from toxic milk to candy laced with arsenic — and explore how those chaotic beginnings shaped the future of food, supplements, and regulation.

Episode 19: KGK Science and Nimble Science: Revolutionizing GI Health Research

In this episode of the Orange Pill Podcast, we talk about the exciting new partnership between KGK Science and Nimble Science. Learn how this collaboration is set to redefine gastrointestinal (GI) health research through the integration of SIMBA™, a novel ingestible capsule that collects high-quality gut samples—without invasive procedures.